近年来,随着临床免疫学和药理学研究的深入,烷化剂环磷酰胺(CPA)已用于除肿瘤性疾病外的一些免疫性疾病。本文结合文献综述如下。一、药理作用 CPA是合成的烷化剂中最为有效而毒性较低的免疫抑制剂,其自身并无活性,需经肝细胞微粒体酶系统转变为具有活性的代谢产物。本品可使核酸烃化,在去氧核糖核酸分子内形成交联,干扰蛋白质的生物 In recent years, along with clinical immunology and pharmacology, the alkylating agent cyclophosphamide (CPA) has been used in some immune diseases besides neoplastic diseases. This article combines the literature is summarized as follows. First, the pharmacological effects of CPA synthetic alkylating agent is the most effective and less toxic immunosuppressive agents, its own activity is not required by the liver cell microsomal enzyme system into an active metabolite. This product can make the nucleic acid alkylation, formation of cross-linked in the DNA molecules, protein-interfering organisms