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乙胺丁醇自1961年作为口服抗结核药而广泛应用。其眼部中毒的特点有:(1)中央视力损害合并中央暗点和辨色力减退Leibold称之为轴型视神经炎。(2)周边视野缺损,无视网膜损害,表现为轴旁型。中毒与用药剂量有关,常发生在用药后22～190天,眼部受累的发生率不高,但是,对每日25mg/kg的剂量不可忽视。对视神经的毒性作用通常是可逆的。异菸肼作为常用的抗结核口服药已25年以上,它对神经系统是有毒性的,其毒性的主要表现是周围神经病。
Ethambutol has been widely used as an oral anti-TB drug since 1961. The characteristics of the eye poisoning are: (1) the central visual acuity combined with dark spots and color discrimination Leibold called axial optic neuritis. (2) Peripheral visual field defect, no retinal damage, manifested as axial type. Poisoning and dosage, often occurs in 22 to 190 days after treatment, the incidence of ocular involvement is not high, however, the daily dose of 25mg / kg can not be ignored. The toxic effect on the optic nerve is usually reversible. Isoniazid as a commonly used anti-TB oral medication for more than 25 years, it is toxic to the nervous system, the main manifestation of toxicity is peripheral neuropathy.