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目的探讨胞二磷胆碱、氯脂醒、神经节苷脂(GM1)对青霉素致疒间大鼠行为学及脑皮层电图的影响,为临床治疗颅脑损伤和外伤后癫疒间提供理论依据。方法制作大鼠癫疒间模型,观察并比较对照组、模型组、胞二磷胆碱组、氯脂醒组、GM1组大鼠的行为学及脑皮层电图表现。结果胞二磷胆碱、氯脂醒、GM1均不能阻止青霉素诱导的大鼠癫疒间发作。胞二磷胆碱、GM1可以延长青霉素诱导的大鼠癫疒间疒间波潜伏期、阵挛强直波潜伏期,减少阵挛强直总时间。结论胞二磷胆碱、氯脂醒、GM1均不能阻止青霉素诱导的大鼠癫疒间发作;胞二磷胆碱、GM1可以延长青霉素诱导的大鼠癫疒间疒间波潜伏期、阵挛强直波潜伏期,减少青霉素腹腔注射后50 m in内的阵挛强直总时间。
Objective To investigate the effects of citicoline, chlorhexidine and gangliosides (GM1) on the behavior and cortical electrogram of penicillin-induced rats and to provide theoretical basis for clinical treatment of traumatic brain injury and epilepsy in accordance with. Methods The model of epilepsy in rats was made. The behavior and cortical electrogram of the rats in the control group, the model group, the citicoline group, the LIP group and the GM1 group were observed and compared. Results Citicoline, chlorhexidine awake, GM1 can not prevent penicillin-induced epileptic seizures in rats. Citicoline and GM1 can prolong the incubation period of penicillin-induced epileptic seizures, the latency of clonic tetanus and decrease the total time of clonic tetanus. Conclusion Citicoline, chlorhexidine, GM1 can not prevent penicillin-induced epileptic seizures in rats; Citicoline and GM1 can prolong the penicillin-induced epileptic seizure latency, Wave latency reduced the total time of clonic tetanus within 50 mins after intraperitoneal injection of penicillin.