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目的检测慢性重型肝炎患者血清胆碱酯酶(ChE)活动度,并与慢性重度肝炎进行对比,探讨ChE活动度对慢性重型肝炎早期诊断及鉴别诊断的临床意义。方法全组120例,慢性重型肝炎组56例,对照组慢性重度肝炎64例。ChE活动度数据均来于患者入院翌晨第1次抽血检测结果,其后复查结果不纳入统计范畴。结果 ChE活动度慢性重型肝炎组为(3 203.46±1 608.98)U/L,对照组为(4 584.53±2 055.02)U/L,两组比较差异有统计学意义(t=4.057,P<0.001)。结论慢性重型肝炎患者在疾病早期ChE活动度已呈现显著降低状态,因此可作为该病早期诊断的重要依据。同时,也可作为慢性重型肝炎与慢性重度肝炎鉴别诊断的重要依据。
Objective To detect serum cholinesterase (ChE) activity in patients with chronic severe hepatitis and compare it with chronic severe hepatitis to explore the clinical significance of ChE activity in the early diagnosis and differential diagnosis of chronic severe hepatitis. Methods The whole group of 120 cases, 56 cases of chronic severe hepatitis group, the control group of 64 cases of chronic severe hepatitis. ChE activity data were collected on the first morning of admission to hospital patients the first blood test results, then the review results are not included in the statistical category. Results The ChE activity of chronic severe hepatitis group was (3 203.46 ± 1 608.98) U / L and that of control group was (5884.53 ± 2 055.02) U / L, the difference was statistically significant (t = 4.057, P <0.001) ). Conclusion The activity of ChE in early stage of disease has been significantly decreased in patients with chronic severe hepatitis, so it can be used as an important basis for the early diagnosis of the disease. At the same time, can also be used as an important basis for the differential diagnosis of chronic severe hepatitis and chronic severe hepatitis.