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目的:探讨高效抗逆转录病毒治疗(HAART)对HIV感染者唾液中人类疱疹病毒5至8型即CMV、HHV-6、HHV-7和HHV-8的分布影响情况。方法:利用巢式PCR技术对受试人群唾液CMV、HHV-6、HHV-7和HHV-8 DNA的存在进行检测,并采用SPSS 18.0软件建立数据库并进行相关指标的统计分析。结果:HIV患者HAART组与非HAART组比较,4种HHV唾液检出率并无差异(P>0.05),HAART组、非HAART组与正常组比较有差异性,而且三组都存在CMV、HHV-6、HHV-7和HHV-8多重感染,HIV人群病毒共同检出率高于正常组,非HAART组高于其它两组。结论:HIV患者中口腔疱疹病毒5-8型感染较为普遍,其中以HHV-6和HHV-7最为突出,HHV-8最低,唾液可能在疱疹病毒传播中起作用。
Objective: To investigate the effect of HAART on the distribution of human herpesvirus types 5 to 8, CMV, HHV-6, HHV-7 and HHV-8 in HIV-infected saliva. Methods: The presence of salivary CMV, HHV-6, HHV-7 and HHV-8 DNA in the test population was detected by nested-PCR. The database was established by SPSS 18.0 software and statistical analysis of related indicators was performed. Results: Compared with non-HAART group, the detection rate of saliva in the four HHV groups was not different between HAART group and non-HAART group (P> 0.05). There was significant difference between HAART group and non-HAART group and CMV, HHV -6, HHV-7 and HHV-8 multiple infections. The common detection rate of HIV in HIV population was higher than that in normal group, and higher in non-HAART group than in other two groups. Conclusion: The oral herpes virus type 5-8 infection is common in HIV patients. Among them, HHV-6 and HHV-7 are the most prominent and HHV-8 is the lowest. Saliva may play a role in herpes virus transmission.