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目的 比较CEDP和CEDH方案治疗中晚期非小细胞肺癌(NSCLC)的有效性和毒性反应。方法 自1994年1月～1998年9月将73例Ⅲ、Ⅳ期NSCLC病人随机分两组,分别应用CEDP方案或CEDH方案进行治疗,观察二种化疗方案的疗效及副作用。结果 CEDP方案与CEDH方案的有效率相近,分别是30.8％和29.4％,对肺鳞癌CEDP方案比CEDH方案的有效率略高,对肺腺癌CEDH方案比CEDP方案的有效率略高,但无统计学差异。CEDP方案与CEDH方案的平均缓解期及中位生存期接近,但CEDH方案的胃肠道反应和骨髓抑制较轻。结论 CEDP方案及CEDH方案均是一种较好的治疗NSCLC方案。CEDH方案由于毒副作用低,对一般状态差以及老年病人更为适合。
Objective To compare the efficacy and toxicity of CEDP with CEDH in the treatment of advanced non-small cell lung cancer (NSCLC). Methods From January 1994 to September 1998, 73 patients with stage Ⅲ and Ⅳ NSCLC were randomly divided into two groups and treated with CEDP or CEDH respectively. The curative effects and side effects of the two chemotherapy regimens were observed. Results The effective rates of CEDP and CEDH were 30.8% and 29.4% respectively. The effective rate of CEDP for lung squamous cell carcinoma was slightly higher than that for CEDH and slightly higher for CEDH than CEDP for lung adenocarcinoma No statistical difference. CEDP regimen and CEDH regimen of the average remission and median survival close, but CEDH regimen less gastrointestinal reactions and bone marrow suppression. Conclusion Both CEDP and CEDH are better treatments for NSCLC. Because of its low toxic side effects, CEDH regimen is more suitable for poor general condition and elderly patients.