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目的比较硫酸吗啡控释片口服和直肠给药对中、重度癌性疼痛的疗效和不良反应。方法中、重度癌痛患者86例随机分为A组(46例)和B组(40例),分别口服或直肠应用硫酸吗啡控释片治疗癌性疼痛。结果A组和B组的疼痛缓解率(84.8%,39/46例对82.5%,33/40例)和不良反应发生率(34.8%,16/46例对45.0%,18/40例)的差异无统计学意义。结论经直肠应用硫酸吗啡控释片控制癌性疼痛与经口给药一样安全、有效。
Objective To compare the efficacy and side effects of oral and rectal administration of morphine sulfate controlled release tablets in patients with moderate and severe cancerous pain. Methods Eighty-six patients with severe cancer were randomly divided into group A (n = 46) and group B (n = 40). Oral or rectal application of morphine sulfate in the treatment of cancer pain. Results The pain relief rate (84.8%, 39/46 vs 82.5%, 33/40) and the incidence of adverse reactions (34.8%, 16/46 vs 45.0%, 18/40) in group A and group B The difference was not statistically significant. Conclusions Transrectal administration of morphine sulfate in the control of cancer pain is as safe and effective as oral administration.