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目的观察多潘立酮联合阿米替林治疗功能性消化不良(FD)的临床效果。方法将医院收治的FD患者72例随机分为观察组与对照组各36例。对照组予以多潘立酮,在此基础上观察组加用阿米替林治疗。观察2组临床效果及症状改善情况。结果观察组患者的总有效率为94.44%高于对照组的75.00%,差异有统计学意义(P<0.05)。2组患者治疗前各项症状积分比较差异无统计学意义(P>0.05);治疗后,2组饱胀、恶心及腹痛症状积分均低于治疗前,且观察组低于对照组(P<0.05)。结论多潘立酮联合阿米替林治疗FD可显著提高疗效,改善患者临床症状,具有临床推广应用价值。
Objective To observe the clinical effect of domperidone combined with amitriptyline in the treatment of functional dyspepsia (FD). Methods Seventy-two FD patients admitted to the hospital were randomly divided into observation group (36 cases) and control group (36 cases). The control group was domperidone, on the basis of the observation group plus amitriptyline treatment. The clinical effect and symptom improvement in 2 groups were observed. Results The total effective rate of observation group was 94.44% higher than 75.00% of control group, the difference was statistically significant (P <0.05). There was no significant difference in symptom scores between the two groups before treatment (P> 0.05). After treatment, scores of symptoms of fullness, nausea and abdominal pain in two groups were lower than those before treatment, and the scores in observation group were lower than those in control group (P < 0.05). Conclusion Domperidone combined with amitriptyline in the treatment of FD can significantly improve the efficacy and improve the clinical symptoms of patients with clinical application value.