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目的 研究原发性肺癌与性激素受体的关系。方法 应用免疫组化SP法对47例患者进行雌激素受体(ER),孕激素受体(PR)及雄激素受体(AR)检测。结果 原发性肺癌的ER、PR及AR阳性率分别为65.95%、61.70%及61.70%。结论 本结果显示肺癌与性激素受体有一定关系,肺癌细胞分化程度越高,性激素受体阳性率越高。通过检测了解肺癌生物学特性,提示内分泌治疗对肺癌性激素受体阳性患者有效,并对预测其预后有一定意义。
Objective To study the relationship between primary lung cancer and sex hormone receptors. Methods The estrogen receptor (ER), progesterone receptor (PR) and androgen receptor (AR) were detected in 47 patients by immunohistochemical SP method. Results The positive rates of ER, PR and AR in primary lung cancer were 65.95%, 61.70% and 61.70%, respectively. Conclusion This study shows that there is a certain relationship between lung cancer and sex hormone receptors. The higher the degree of differentiation of lung cancer cells, the higher the sex hormone receptor positive rate. By examining the biological characteristics of lung cancer, it is suggested that endocrine therapy is effective for sex hormone receptor-positive patients with lung cancer, and it has a certain significance in predicting its prognosis.