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药物的吸收主要是由药物的理化性质、剂型以及给药途径所决定的。原位凝胶是指在生理条件刺激下能发生分散状态或构象的可逆变化、完成溶液与凝胶间相互转变的新剂型。原位凝胶经鼻腔给药,既避免了药物的胃肠首过效应,又因其能延长药物在给药部位滞留时间,从而避免药物被鼻纤毛快速清除。本文通过系统查阅近年国内外鼻用原位凝胶给药系统的相关文献,就鼻腔的生理特点、药物理化性质与原位凝胶的制剂处方等影响其药物吸收的主要因素及改进措施,进行分析、整理和归纳,旨在为鼻用原位凝胶给药系统的设计与质量控制提供参考。
Drug absorption is mainly determined by the physical and chemical properties of drugs, dosage forms and route of administration. In-situ gels are reversible changes in the state of dispersion or conformation that can occur under physiological stimuli and accomplish new forms of transformation between the solution and the gel. In situ gel nasal administration, both to avoid the first gastrointestinal effect of the drug, but also because it can prolong the residence time in the drug delivery site, thus avoiding the rapid clearance of drugs by the nasal cilia. In this paper, we systematically reviewed the relevant literature of nasal in-situ gel delivery system in recent years and discussed the main factors that affect the absorption of the drug and the improvement measures of the physiological characteristics of the nasal cavity, the physico-chemical properties of the nasal cavity and the prescription of the gel in situ Analysis, collation and induction, designed to provide a reference for the design and quality control of nasal in situ gel delivery system.