恶性淋巴瘤胸膜腔浸润引起顽固性胸水,临床处理比较棘手。最近我们遇到二例恶性淋巴瘤反复大量胸水,仅用全身化疗加抽吸胸水,无法控制胸水渗出;后来加用胸膜腔内注射环磷酰胺法,胸水获得控制,留下胸膜增厚,解除了患者的长期烦恼。例1 住院号34526,李××,男性,40岁。因发现颈部肿块半年,经淋巴活检,确诊为淋巴肉瘤,临床分期Ⅳ_(?);不久右侧胸腔出现大量积液,引起呼吸困难。在10个月的时间内,经过多疗程COPP方案,先后抽吸胸水5次。开始尚能控制,后来胸水越来越顽固,抽后周余又有大量胸水渗出,患者十分苦恼。因此采用胸膜腔内注药法,即在 Malignant lymphoma pleural infiltration caused by intractable pleural effusion, the clinical treatment more difficult. Recently, we encountered two cases of malignant lymphoma repeatedly pleural effusion, only with systemic chemotherapy plus suction pleural effusion, can not control pleural effusion; later added intrapleural injection of cyclophosphamide, pleural effusion control, leaving pleural thickening, Lifted the patient’s long-term trouble. Example 1 Hospital number 34526, Lee × ×, male, 40 years old. Due to the discovery of cervical mass for six months, lymph node biopsy, diagnosed as lymphosarcoma, clinical stage Ⅳ_ (?); Shortly after the right pleural effusion, causing breathing difficulties. In 10 months time, after multiple courses of COPP program, has pleural effusion 5 times. The beginning can still control, and later more and more stubborn pleural effusion, after pumping more than a week there is a lot of pleural effusion, the patient is very distressed. Therefore, the use of pleural cavity injection method, that is