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胃十二指肠疾病主要发病机理是胃的激素调节障碍,胃泌素具有重要作用,它是由胃窦部G细胞分泌,是消化腺主要兴奋剂,能刺激胃酸、胃蛋白酶分泌,释放组织胺,分泌胰岛素,对胃粘膜的营养有刺激作用。G细胞还分泌促肾上腺皮质激素(ACTH)生长激素(GH)和内啡肽。无论来源于垂体或胃的ACTH、GH对胃泌素的合成均有增强作用。现已证实垂体激素直接参与胃消化功能调节,在其相互关系失调时可产生胃十二指肠病变(应激反应)。作者用放射免疫法测定157例8～14岁慢性胃十二指肠炎患儿血中胃泌素、ACTH、GH含量,其中极期95例,缓解期62例,并以15例正常儿童作为对照,探讨激素含量与疾病的关系,用于诊断。检查结
Gastricoduodenal disease is the main pathogenesis of gastric hormonal dysregulation, gastrin has an important role, it is secreted by the gastric G cells, is the main digestive gland stimulants, can stimulate gastric acid, pepsin secretion, release of tissue Amines, insulin secretion, the nutrition of gastric mucosa stimulation. G cells also secrete adrenocorticotropic hormone (ACTH) growth hormone (GH) and endorphins. Whether derived from the pituitary or stomach ACTH, GH on the synthesis of gastrin have enhanced role. It has been confirmed that pituitary hormones directly involved in the regulation of gastric digestive function, in the relationship between disorders can produce gastroduodenal lesions (stress response). The authors used radioimmunoassay 157 cases of 8-14 years old children with chronic gastritis in children with chronic gastroduodenal enteritis gastrin, ACTH, GH content, including 95 cases of extreme, remission in 62 cases, and 15 cases of normal children as a control , To explore the relationship between hormone content and disease for diagnosis. Check the knot