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目的 评价超分割放射治疗对鼻咽癌患者正常组织的保护作用。方法 从 1995年 1月至 1997年 1月 ,经过面颈联合野治疗的鼻咽癌患者 4 8例 ,其中 31例患者采用常规分割放射治疗 ,总量为 6 5～ 75Gy。另外 17例患者采用常规分割照射 36Gy后 ,又给予超分割照射 ,即 1 5Gy 次 ,每日两次 ,再给 30～ 36Gy。病人均于疗前、疗终及治疗结束 3个月及以后行CT检查。结果 治疗结束后 ,常规照射组上颌窦炎的发生率为 2 2 6 % ,而常规 +超分割组为 35 3% ,但是 3个月后常规分割组上颌窦炎的发生率为 32 3% ,而常规 +超分割组为 11 8%。结论 上颌窦受照体积越大 ,其上颌窦炎发生时间越早 ,程度越重。但随时间延长两者差异越来越不明显。超分割照射对正常组织有保护作用 ,可减少后遗症的发生。
Objective To evaluate the protective effect of hyperfraction radiotherapy on normal tissues of patients with nasopharyngeal carcinoma. Methods From January 1995 to January 1997, 48 patients with nasopharyngeal carcinoma treated by face-and-neck combined field therapy were enrolled. Among them, 31 patients underwent routine fractionated radiotherapy, with a total amount of 65-75 Gy. Another 17 patients with conventional segmentation 36Gy irradiation, but also give hyperfractionated irradiation, that is 15Gy times, twice daily, and then give 30 ~ 36Gy. Patients were in the pre-treatment, end of treatment and end of treatment after 3 months and after CT examination. Results After the treatment, the incidence of maxillary sinusitis was 2.2% in the conventional irradiation group and 35.3% in the conventional ultrasonography group, but the incidence of maxillary sinusitis in the conventional group was 32.3% after 3 months, While the conventional + hyperfractionation group was 118%. Conclusion The maxillary sinus irradiation volume is larger, the maxillary sinusitis occurs earlier, the more severe. But with the passage of time the difference between the two is less and less obvious. Superfractionated irradiation has a protective effect on normal tissues, can reduce the occurrence of sequelae.