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目的探讨双歧杆菌四联活菌联合谷维素作用于肠易激综合征的临床效果。方法 52例肠易激综合征患者,采用电脑随机分组的方式分为观察组(28例)和对照组(24例)。两组患者在门诊收治后均接受匹维溴铵口服治疗,在此基础上观察组采用双歧杆菌四联活菌联合谷维素治疗,对照组采用谷维素治疗。比较两组患者的治疗效果、精神状态及不良反应发生情况。结果观察组治疗总有效率高于对照组,差异具有统计学意义(χ~2=4.3797,P<0.05)。治疗后,观察组汉密尔顿抑郁量表(HAMD)评分为(10.1±2.3)分,低于对照组的(12.7±3.4)分,差异具有统计学意义(t=3.2691,P<0.05);观察组汉密尔顿焦虑量表(HAMA)评分为(9.9±2.6)分,低于对照组的(12.1±2.9)分,差异具有统计学意义(t=2.8842,P<0.05)。两组不良反应发生率比较差异无统计学为意义(P>0.05)。结论在肠易激综合征的临床治疗中加入双歧杆菌四联活菌联合谷维素治疗具有较好的临场效果,方法值得借鉴。
Objective To investigate the clinical effect of live bifidobacterium combined with oryzanol on irritable bowel syndrome. Methods Fifty - two patients with irritable bowel syndrome were randomly divided into observation group (n = 28) and control group (n = 24). Both groups received oral pinaverium bromide treatment after their outpatient treatment. On the basis of this, the observation group was treated with live bifidobacterium viable combined with oryzanol and the control group with oryzanol. The treatment effect, mental status and adverse reactions of the two groups were compared. Results The total effective rate of observation group was higher than that of control group, the difference was statistically significant (χ ~ 2 = 4.3797, P <0.05). After treatment, the HAMD score of the observation group was (10.1 ± 2.3) points lower than that of the control group (12.7 ± 3.4) points, the difference was statistically significant (t = 3.2691, P <0.05) The Hamilton Anxiety Scale (HAMA) score was (9.9 ± 2.6) points, which was lower than that of the control group (12.1 ± 2.9) points. The difference was statistically significant (t = 2.8842, P <0.05). No significant difference was found in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion In the clinical treatment of irritable bowel syndrome, Bifidobacterium viable combined with oryzanol treatment has better on-site effect, the method is worth learning from.