目的:观察序贯疗法根除幽门螺杆菌(Hp)与降低消化性溃疡(PU)复发的效果,探寻适合于官兵的根除Hp方案。方法:Hp阳性官兵PU 1608例为观察组,采用抗HP一线方案:奥美拉唑联合呋喃唑酮和甲硝唑。未达根除者采用补救方案1(奥美拉唑联合阿莫西林和呋喃唑酮)或补救方案2(奥美拉唑联合左氧氟沙星和阿莫西林)。另选择未接受规范抗HP治疗的PU官兵1019例为对照组。结果:一线方案及补救方案1、方案2的Hp根除率分别为85.1%、87.0%、89.2%,观察组溃疡愈合率显著高于对照组(P<0.05),溃疡复发率非常显著低于对照组(P<0.01)。结论:采用序贯疗法给予补救方案1、方案2对初次根除Hp治疗失败者是有效补充,且疗效可靠,价格低廉,不良反应少,适宜部队推广应用。 Objective: To observe the efficacy of sequential therapy in eradicating Helicobacter pylori (Hp) and reduce the recurrence rate of peptic ulcer (PU), and to search for the eradication Hp program suitable for officers and men. Methods: A total of 1608 Hp-positive officers and soldiers were randomly divided into observation group and anti-HP first-line regimen: omeprazole combined with furazolidone and metronidazole. Remedies 1 (omeprazole in combination with amoxicillin and furazolidone) or remediation option 2 (omeprazole in combination with levofloxacin and amoxicillin) were used in less than eradication patients. In addition, 1019 PU officers and soldiers who did not receive standard anti-HP treatment were selected as the control group. Results: The Hp eradication rates of first-line protocol and remediation protocol 1 and protocol 2 were 85.1%, 87.0% and 89.2% respectively. The healing rate of ulcer in observation group was significantly higher than that of control group (P <0.05), and the recurrence rate of ulcer was significantly lower than that of control group Group (P <0.01). CONCLUSIONS: Remedial protocol 1 is given by sequential therapy. Option 2 is an effective supplement to those patients who failed the initial eradication of Hp therapy. The treatment is reliable, inexpensive and has few adverse reactions. It is suitable for the promotion and application of the force.