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目的:对比单纯主动免疫治疗和主动免疫联合HCG及黄体酮安胎治疗原因不明自然流产的疗效,探讨临床治疗原因不明习惯性流产的适宜方案。方法:205例原发性或继发性原因不明习惯性流产患者随机分为2组。A组105例,接受主动免疫治疗,妊娠后立即联合HCG及黄体酮安胎治疗;B组100例,单纯接受主动免疫治疗。结果:治疗后A组妊娠成功率为90.48%(95/105),B组妊娠成功率为83.00%(83/100),A组、B组比较差异无统计学意义(P>0.05)。205例主动免疫治疗后封闭抗体转为阳性133例,其中113例成功妊娠,妊娠成功率84.96%,封闭抗体仍为阴性72例中,成功妊娠58例,妊娠成功率80.56%,二者比较差异无统计学意义。结论:主动免疫治疗原因不明自然流产原则上不需联合HCG及黄体酮安胎治疗;可根据个体情况联合应用HCG及黄体酮安胎治疗;主动免疫治疗后封闭抗体转阳与否与妊娠结局无相关性。
OBJECTIVE: To compare the curative effect of simple active immunotherapy and active immunization combined with HCG and progesterone on unexplained spontaneous abortion, and to explore the suitable protocol for clinical treatment of unexplained habitual abortion. Methods: 205 cases of primary or secondary unexplained habitual abortion were randomly divided into two groups. A group of 105 patients received active immunotherapy, pregnancy and progesterone combined with HCG and progesterone treatment; B group of 100 patients, simply receiving active immunotherapy. Results: The success rate of pregnancy in group A was 90.48% (95/105) after treatment. The success rate of pregnancy in group B was 83.00% (83/100). There was no significant difference between group A and group B (P> 0.05). Of the 205 active immunotherapy, the positive clones turned positive into 133, of which 113 were successful, the success rate of pregnancy was 84.96%, and the number of closed antibody was still negative. Of the 72 cases, 58 were successful and the pregnancy success rate was 80.56% No statistical significance. Conclusion: The reasons of active immunotherapy unknown spontaneous abortion in principle without the combination of HCG and progesterone treatment of progesterone; can be combined according to individual circumstances HCG and progesterone treatment of progesterone; active immunotherapy after blocking the positive or negative pregnancy and pregnancy outcome Correlation.