目的分析非良性卵巢肿瘤患者保留生育功能治疗后影响妊娠能力的因素、母儿结局及孕期保健中存在的问题。方法对2000年1月至2010年4月北京大学人民医院收治的年龄≤40岁、未完成生育功能、因交界性或恶性卵巢肿瘤行保留生育功能治疗的患者进行电话随访,有生育要求、解除避孕措施≥1年者纳入研究,分为妊娠组和未妊娠组。结果符合条件患者57例,成功随访42例,纳入研究23例。妊娠组12例,未妊娠组11例。妊娠距离初次治疗后的中位时间为10个月(3～60个月);未妊娠组既往有不育病史、行全面分期手术、分期超过Ⅰ期的患者比例高于妊娠组(P<0.05),而仅行肿物剥除术的患者治疗后妊娠率高于行附件切除术的患者(P<0.05)。母儿并发症以胎膜早破、流产、早产和新生儿高胆红素血症发生次数较多。妊娠组肿瘤复发3例,2例发生在妊娠晚期。结论既往不育病史、保留生育功能手术类型、是否行全面分期手术及肿瘤分期影响非良性卵巢肿瘤患者保留生育功能治疗后的妊娠能力;妊娠后应加强围产期保健,特别是对肿瘤复发的监测。 Objective To analyze the factors influencing pregnancy ability after maternal reproductive function maintenance in patients with benign ovarian tumors, maternal and infant outcomes and problems in prenatal care. Methods From January 2000 to April 2010 Peking University People ’s Hospital admitted to the age of 40 years of age, did not complete reproductive function, due to borderline or malignant ovarian tumor patients with reproductive function during telephone follow-up, fertility requirements, lift Contraceptive measures ≥ 1 year were included in the study, divided into pregnancy and non-pregnant group. Results 57 eligible patients were successfully followed up in 42 cases and 23 cases were included in the study. 12 cases of pregnancy group, 11 cases of non-pregnancy group. The median length of pregnancy after the first treatment was 10 months (range, 3 to 60 months). The non-pregnancy group had a history of infertility and had a complete staging operation. The proportion of patients with staging stage Ⅰ was higher than that of the pregnancy group (P <0.05) ), While those who underwent exenteration had a higher pregnancy rate than those who underwent adjuvant resection (P <0.05). Maternal and child complications of premature rupture of membranes, abortion, premature birth and neonatal hyperbilirubinemia occurred more frequently. Pregnancy group tumor recurrence in 3 cases, 2 cases occurred in the third trimester of pregnancy. Conclusion The history of infertility, retention of reproductive function type of surgery, whether a comprehensive phased operation and tumor staging affect the ability of pregnant women with non-benign ovarian tumor to retain their reproductive function after pregnancy; pregnancy should be strengthened perinatal care, especially for tumor recurrence monitor.