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目的观察补气托毒消痈方治疗幽门螺杆菌相关性胃炎的临床疗效。方法将80例幽门螺杆菌相关性胃炎患者随机分为治疗组和对照组,每组40例。对照组予标准三联疗法,治疗组在对照组治疗措施的基础上加予补气托毒消痈方。两组疗程均为14天,观察临床疗效、不良反应,比较中医证候积分、Hp清除率;随访6个月观察复发率。结果 1治疗组、对照组临床总有效率分别为95.00%和77.50%;组间临床疗效比较,差异有统计学意义(P<0.05)。2治疗前后组内比较,两组中医证候积分差异有统计学意义(P<0.05);组间治疗后比较,中医证候积分差异有统计学意义(P<0.05)。3治疗组与对照组Hp清除率分别为90.00%、72.50%;组间Hp清除率比较,差异有统计学意义(P<0.05)。4随访期间,治疗组复发2例(5.56%),对照组复发6例(20.69%);组间复发率比较,差异有统计学意义(P<0.05)。5组间不良反应发生率比较,差异无统计学意义(P>0.05)。结论补气托毒消痈方联合三联疗法治疗幽门螺杆菌相关性胃炎,可显著清除Hp,且复发率较低。
Objective To observe the clinical curative effect of Bu Tong Tu Du Xiaoyan Recipe in treating Helicobacter pylori associated gastritis. Methods 80 cases of Helicobacter pylori-associated gastritis were randomly divided into treatment group and control group, 40 cases in each group. Control group to standard triple therapy, the treatment group in the control group based on the treatment measures to add gas Toxu Xiao Fang side. The two groups were treated for 14 days, the clinical efficacy, adverse reactions, TCM syndrome scores, Hp clearance rate; follow-up of 6 months to observe the recurrence rate. Results 1 The total clinical effective rates of the treatment group and the control group were 95.00% and 77.50%, respectively. There were significant differences in clinical efficacy between the two groups (P <0.05). There were significant differences in TCM syndrome scores between the two groups before and after treatment (P <0.05). After treatment, the differences of TCM syndrome scores were statistically significant (P <0.05). The Hp clearance rates of the treatment group and the control group were 90.00% and 72.50%, respectively. There was significant difference between the two groups in the Hp clearance rate (P <0.05). During the follow-up period, there were 2 cases (5.56%) in the treatment group and 6 cases (20.69%) in the control group. The recurrence rate was significantly different between the two groups (P <0.05). There was no significant difference in the incidence of adverse reactions between the 5 groups (P> 0.05). Conclusion Bu Tong Tudu Xiaoyan decoction combined with triple therapy for Helicobacter pylori-associated gastritis can significantly clear Hp, and the recurrence rate is low.