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色素上皮源性因子 (Pigmentepithelium derivedfactor ,PEDF)是一种存在于正常组织中的可溶性糖蛋白。它具有营养和保护神经、抑制血管形成、促进肿瘤分化和凋亡等功能。PEDF是近年来国外研究较多的肿瘤生长和转移抑制因子之一 ,它的发现和其对肿瘤作用机制的阐明 ,对于人类恶性肿瘤的基础研究和临床应用具有重要的意义。
Pigmentepithelium derived factor (PEDF) is a soluble glycoprotein found in normal tissues. It has the functions of nourishing and protecting nerves, inhibiting blood vessel formation, promoting tumor differentiation and apoptosis. PEDF is one of the most important tumor growth and metastasis suppressors in recent years. Its discovery and elucidation of its mechanism of action on tumor are of great significance to the basic research and clinical application of human malignant tumors.