目的用细胞遗传学方法明确Down′s综合征患儿的诊断,为优生干预提供科学依据。方法采用外周血淋巴细胞培养,G显带技术染色体核型分析。结果38例患儿被确诊为Down′s综合征,其中男性23例,女性15例,与生母年龄的相关性为≥35岁占34.21%,(35岁占65.79%。结论Down′s综合征是临床上较常见的遗传性疾病,因其无有效的治疗方法,开展产前筛查、产前诊断是防治本病的有效手段。 Objective To clarify the diagnosis of Down’s syndrome in children by cytogenetics and provide a scientific basis for the intervention of eugenics. Methods Peripheral blood lymphocytes were cultured and analyzed by G - banding technique. Results 38 children were diagnosed with Down’s Syndrome, including 23 males and 15 females, with a correlation of ≥35 years old with 34.21% (35 years old, 65.79%). Conclusion Down’s syndrome Is a more common clinical genetic disease, because there is no effective treatment, to carry out prenatal screening, prenatal diagnosis is an effective means of prevention and treatment of this disease.