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目的探讨无创双水平正压通气在COPD合并呼吸衰竭中的应用。方法 2008年2月—2010年9月收治的280例COPD合并呼吸衰竭患者,随机分为常规治疗组142例,无创正压通气组138例,观察两组临床效果。结果两组治疗前血PH值、PaO2、PaCO2比较无显著差异性(P>0.05)。两组治疗24h后、治疗72h后血PH值、PaO2、PaCO2比较有显著差异性(P<0.05)。两组气管插管率;两组病死率、平均住院日比较有显著差异性(P<0.05)。结论无创双水平正压通气在COPD合并呼吸衰竭治疗中临床疗效确切,改善患者临床症状,改善肺通气和肺换气,可以明显降低病死率。
Objective To explore the application of noninvasive bi-level positive pressure ventilation in COPD with respiratory failure. Methods A total of 280 COPD patients with respiratory failure who were admitted to our hospital from February 2008 to September 2010 were randomly divided into routine treatment group (n = 142) and noninvasive positive pressure ventilation group (n = 138). The clinical effects were observed. Results There was no significant difference in PH, PaO2 and PaCO2 between the two groups before treatment (P> 0.05). After treatment for 24 h, the blood PH value, PaO2 and PaCO2 in 72 h after treatment were significantly different (P <0.05). Tracheal intubation rate of two groups; two groups of mortality, the average length of stay were significantly different (P <0.05). Conclusions Noninvasive bi-level positive pressure ventilation has definite curative effect in the treatment of COPD with respiratory failure, and can improve clinical symptoms, improve pulmonary ventilation and pulmonary ventilation, and can significantly reduce the mortality.