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目的：测定宫颈癌及癌旁组织中脂质过氧化物（LPO）及超氧化物歧化酶（SOD）的临床意义。方法：应用黄嘌呤氧化酶和硫代巴比妥酸法对32例宫颈癌患者的宫颈癌组织及癌旁组织进行LPO及SOD测定。结果：宫颈癌组织中LPO的含量及SOD活性明显高于癌旁组织之对照组，差异非常显著P<0．01。结论：自由基代谢紊乱引发DNA脱氢、断键、发生畸变是致癌的主要因素。
Objective: To determine the clinical significance of lipid peroxides (LPO) and superoxide dismutase (SOD) in cervical cancer and adjacent tissues. Methods: The expressions of LPO and SOD in cervical cancer tissues and adjacent tissues of 32 patients with cervical cancer were determined by xanthine oxidase and thiobarbituric acid method. Results: The content of LPO and the activity of SOD in cervical cancer tissues were significantly higher than those in the adjacent non-cancerous tissues (P <0.01). Conclusion: Free radical metabolism caused by DNA dehydrogenation, bond breaking, the occurrence of distortion is the main factor of carcinogenesis.