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目的:探讨聚糖纳米粒载导的阿霉素移植瘤小鼠的体内抑瘤作用。方法:利用研制的聚乳酸阿霉素纳米粒对移植瘤小鼠的抑瘤作用,并选取生理盐水、空白脂质体以及游离阿霉素作为对照组,观察各组体内抑瘤情况。结果:聚乳酸阿霉素纳米粒组动物平均瘤重较对应游离阿霉素组明显减轻,药物抑瘤率显著提高(P<0.05),两组治疗组较生理盐水对照组、空白脂质体对照组抑瘤率有显著提高(P<0.05),而空白脂质体组与生理盐水对照组抑瘤率无显著差异(P>0.05)。结论:聚糖纳米粒阿霉素对移植瘤小鼠的体内抑瘤作用较游离阿霉素效果显著,作用时间更持续长久。
Objective: To investigate the antitumor effect of polysaccharide nanoparticles-loaded adriamycin xenografted mice in vivo. Methods: The anti-tumor effect of the prepared polylactic acid doxorubicin nanoparticles on tumor-bearing mice was studied. Normal saline, blank liposome and free doxorubicin were selected as the control group, and the anti-tumor effect in each group was observed. Results: The average tumor weight of the polylactic acid doxorubicin nanoparticles group was significantly lower than that of the corresponding free doxorubicin group, and the tumor inhibition rate of the drug group was significantly increased (P <0.05). Compared with the saline control group, the blank liposomes The tumor inhibition rate of the control group was significantly increased (P <0.05), while the inhibition rate of the liposome group and the saline control group had no significant difference (P> 0.05). Conclusion: The antitumor effect of polysaccharide nanoparticle doxorubicin on xenografts in mice is more effective than free doxorubicin, and the duration of action is longer and longer.