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目的观察胆囊收缩素受体ｍＲＮＡ在胆管癌中的表达。方法应用原位杂交技术检测了４２例胆管癌标本中胆囊收缩素－Ａ、胆囊收缩素－Ｂ／胃泌素受体ｍＲＮＡ的表达。结果３８例（９０．５％）胆管癌标本有胆囊收缩素－Ｂ／胃泌素受体ｍＲＮＡ的表达，２０例（４７．６％）标本有胆囊收缩素－Ａ受体ｍＲＮＡ的表达，１５例标本同时表达胆囊收缩素－Ａ受体ｍＲＮＡ和胆囊收缩素－Ｂ／胃泌素受体ｍＲＮＡ；胆囊收缩素－Ｂ／胃泌素受体ｍＲＮＡ表达量显著高于胆囊收缩素－Ａ受体ｍＲＮＡ；两种受体ｍＲＮＡ的表达量与胆管癌的部位无关，而与其分化程度有关，分化程度越高，表达量越多。结论胆管癌有胆囊收缩素受体ｍＲＮＡ表达，表达量与分化程度密切相关。
Objective To observe the expression of cholecystokinin receptor mRNA in cholangiocarcinoma. Methods In situ hybridization was used to detect the expression of cholecystokinin-A and cholecystokinin-B/gastrin receptor mRNA in 42 cases of cholangiocarcinoma. Results The expression of cholecystokinin-B/gastrin receptor mRNA was detected in 38 cases (90.5%) of cholangiocarcinoma specimens, and the cholecystokinin-A receptor mRNA was expressed in 20 specimens (47.6%). 15 The specimens also expressed cholecystokinin-A receptor mRNA and cholecystokinin-B/gastrin receptor mRNA; the expression of cholecystokinin-B/gastrin receptor mRNA was significantly higher than that of cholecystokinin-A receptor mRNA; The expression levels of the two receptor mRNAs have nothing to do with the location of cholangiocarcinoma, but related to its degree of differentiation. The higher the degree of differentiation, the greater the amount of expression. Conclusion There is cholecystokinin receptor mRNA expression in cholangiocarcinoma, and the expression level is closely related to the degree of differentiation.