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目的:研究复方三茶蜜丸对小鼠S180实体瘤的抑制作用、对肝癌H22腹水瘤小鼠生存期的影响及对环磷酰胺治疗小鼠S180实体瘤的增效作用。方法:以环磷酰胺和氟尿嘧啶为阳性对照药,观察复方三茶蜜丸对荷瘤S180和肝癌H22腹水瘤小鼠瘤重、抑瘤率及生命延长率的影响,以及对环磷酰胺治疗小鼠S180实体瘤瘤重、抑瘤率的影响。结果:复方三茶蜜丸高、中、低剂量组(6,3,1.5 g·kg-1)连续ig 10 d后对S180小鼠的抑瘤率分别为38.1%,13.2%,2.1%,与剂量呈正相关,其中高剂量组S180小鼠的瘤重显著减轻(P<0.05);用药后肝癌H22小鼠的生命延长率分别是31.9%,30.5%,5.0%,与剂量呈一定的正相关,其中高、中剂量可明显延长肝癌H22腹水瘤小鼠的生存期(与对照组比较P<0.05);联合环磷酰胺用药后S180小鼠的抑瘤率分别为79.7%,74.7%,76.4%,S180小鼠的瘤重显著减轻(与对照组比较P<0.01);与单用复方三茶蜜丸组比较,S180小鼠的瘤重显著减轻(P<0.01或P<0.05)。结论:复方三茶蜜丸可抑制小鼠S180肿瘤生长,延长肝癌H22腹水瘤小鼠生存期,对环磷酰胺治疗小鼠S180实体瘤有增效作用。
Objective: To study the inhibitory effect of Fufang Sanchami Pill on S180 solid tumor in mice and its effect on the survival of H22 ascites tumor in mice and its synergistic effect on S180 solid tumor in mice treated with cyclophosphamide. Methods: Cyclophosphamide and fluorouracil were used as positive control drugs to observe the effects of Fufang Sanchamiwan on tumor weight, tumor inhibition rate and life extension rate of S180 and H22 ascitic tumor mice, S180 solid tumor weight, tumor inhibition rate. RESULTS: The inhibitory rates of S180 mice in high, medium and low dose groups (6, 3, 1.5 g · kg-1) for 10 days were 38.1%, 13.2% and 2.1% (P <0.05). The life prolongation of H22 mice was 31.9%, 30.5% and 5.0%, respectively, which was positively correlated with the dose (P <0.05). The inhibitory rates of S180 mice treated with cyclophosphamide were 79.7%, 74.7%, respectively, The tumor weight of S180 mice was significantly lower than that of the control group (P <0.01 or P <0.01). Compared with the control group, S180 mice had significantly reduced tumor weight (P <0.01 or P <0.05). Conclusion: Sanchami pill can inhibit the growth of S180 tumor in mice, prolong the survival of H22 ascites tumor in mice, and have a synergistic effect on S180 solid tumor in mice treated with cyclophosphamide.