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4-1BB和4-1BB配体(4-1BBL)为肿瘤坏死因子/肿瘤坏死因子受体(TNF/TNFR)超家属的成员。研究发现,4-1BB和4-1BBL相互作用产生的共刺激信号在机体肿瘤免疫中起重要作用。本文通过对4-1BB/4-1BBL在共刺激作用的研究,探讨其在口腔癌免疫治疗中的潜在作用。
4-1BB and 4-1BB ligands (4-1BBL) are members of the tumor necrosis factor / tumor necrosis factor receptor (TNF / TNFR) superfamily. The study found that co-stimulatory signals generated by the interaction of 4-1BB and 4-1BBL play an important role in tumor immunity. In this paper, we investigated the potential role of 4-1BB / 4-1BBL in co-stimulatory effects in oral cancer immunotherapy.