非离子型表面活性剂常用作药用及化妆用分散体的润湿剂、乳化剂和稳定剂,其界面性质显著地受它们溶解状况的影响。各种附加剂如盐类可影响非离子型表面活性剂极性部分的水合作用,从而改变了乳状液的相转化温度。某些醇类能增加聚氧乙烯壬酚酯的水合作用,而对其他表面活性剂则起相反作用。颗粒的絮凝作用是影响药用混悬液贮存期稳定性的重要因素。反絮凝的混悬液倾向于结块。一般情况下,絮凝体较易重新分散。在含有非离子型表面活性剂的混悬液中,加入附加剂很可能影响表面活性剂的水合状态,并改变混悬液的絮凝程度,因此必须慎重选择药用混悬液附加剂。选用硫酸钠和丙二醇作为附加剂。磺胺 Nonionic surfactants are commonly used as wetting agents, emulsifiers and stabilizers for pharmaceutical and cosmetic dispersions and their interfacial properties are significantly affected by their dissolution profile. Various additives, such as salts, can affect the hydration of the polar portion of the non-ionic surfactant, thereby altering the phase transition temperature of the emulsion. Some alcohols increase the hydration of polyoxyethylene nonylphenols, but do the opposite for other surfactants. Particulate flocculation is an important factor that affects the stability of pharmaceutical suspensions during storage. The deflocculated suspension tends to agglomerate. In general, flocs are more easily redispersed. In suspensions containing non-ionic surfactants, addition of adjuvants is likely to affect the surfactant’s hydration status and alter the degree of flocculation of the suspension, so care-inducing suspensions must be carefully selected. Use sodium sulfate and propylene glycol as an additive. Sulfonamide