论文部分内容阅读
目的:评价血清骨保护素(OPG)水平在冠心病合并肺动脉高压中的意义。方法:将70例冠心病患者依据肺动脉收缩压(PASP)分为冠心病合并肺动脉高压组(PASP≥30 mm Hg,23例)和冠心病无肺动脉高压组(PASP<30 mm Hg,47例)。应用超声心动图测定其心功能,并采用酶联免疫吸附试验(ELISA)检测患者血清中的OPG水平。结果:与冠心病无肺动脉高压组相比,冠心病合并肺动脉高压组患者的左心房内径(LAD)、左心室舒张末期内径(LVEDD)、左心室舒张末期容量(LVEDV)和左心室收缩末期内径(LVESD)、左心室收缩末期容量(LVESV)均明显增加(P均<0.05),其中LAD与PASP呈正相关(r=0.736,P<0.001)。同时,冠心病合并肺动脉高压患者的血清OPG水平明显高于冠心病无肺动脉高压者(P<0.05),且其OPG水平与部分左心室指标呈正相关(P均<0.05)。结论:血清OPG水平能反映左心室指标的变化,进而可预测冠心病患者肺动脉高压的发生;与此同时,OPG还可能促使冠心病合并肺动脉高压患者的肺动脉压进一步升高。
Objective: To evaluate the significance of serum osteoprotegerin (OPG) level in patients with coronary heart disease complicated with pulmonary hypertension. Methods: Seventy patients with coronary heart disease were divided into two groups according to pulmonary artery systolic pressure (PASP): coronary heart disease complicated with pulmonary hypertension (PASP≥30 mm Hg, 23 cases) and coronary heart disease without pulmonary hypertension (PASP <30 mm Hg, 47 cases) . Cardiac function was measured by echocardiography, and serum OPG levels were measured by enzyme-linked immunosorbent assay (ELISA). Results Compared with CHD patients without PAH, left atrium diameter (LAD), left ventricular end diastolic dimension (LVEDD), left ventricular end diastolic volume (LVEDV) and left ventricular end-systolic diameter (LVESD) and left ventricular end-systolic volume (LVESV) were significantly increased (all P <0.05). There was a positive correlation between LAD and PASP (r = 0.736, P <0.001). At the same time, serum OPG level in CHD patients with pulmonary hypertension was significantly higher than that in CHD patients without pulmonary hypertension (P <0.05), and the OPG level was positively correlated with some left ventricular parameters (all P <0.05). CONCLUSIONS: Serum OPG level can reflect the changes of left ventricular index, and then can predict the occurrence of pulmonary hypertension in patients with coronary heart disease. Meanwhile, OPG may further promote pulmonary hypertension in patients with coronary heart disease complicated with pulmonary hypertension.