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目的探讨甘氨双唑钠联合小剂量顺铂对中晚期食管癌同期放疗的增敏作用并评估其应用前景。方法 62例中晚期食管癌患者全部采用三维适形放射治疗,总剂量60~70 Gy。所有患者被先后随机地(机械抽样法)分成A、B两组。A组:顺铂每天10 mg,连续静脉滴注5天,周一至周五;应用甘氨双唑钠700 mg/m2于放疗前静脉滴注,每周3次,用药后1小时内接受放疗。B组:为对照组,仅应用甘氨双唑钠700 mg/m2于放疗前静脉滴注,每周3次,用药后1小时内接受放疗。结果治疗结束后1月进行疗效评价,甘氨双唑钠联合小剂量顺铂总有效率为93.3%;对照组总有效率为70.0%,两组比较差异有统计学意义(P<0.05)。结论甘氨双唑钠联合小剂量顺铂放疗增敏能提高中晚期食管癌的放疗效果,且较单用甘氨双唑钠放疗增敏效果好。
Objective To investigate the sensitizing effect of glycididazole combined with low-dose cisplatin on concurrent esophageal cancer radiotherapy and to evaluate its application prospects. Methods Sixty-two patients with advanced esophageal cancer were treated with three-dimensional conformal radiotherapy at a total dose of 60-70 Gy. All patients were randomized (mechanical sampling method) into A, B two groups. Group A: cisplatin 10 mg daily, continuous intravenous infusion of five days, Monday to Friday; application of glycopyrrolate sodium 700 mg / m2 intravenous infusion before radiotherapy, three times a week, within 1 hour after receiving radiotherapy . Group B: the control group, only the application of glycopyrrolate sodium 700 mg / m2 intravenous drip before radiotherapy, three times a week, within 1 hour after receiving radiotherapy. Results The therapeutic effect was evaluated in January after the treatment. The total effective rate of sodium glycididazole combined with low-dose cisplatin was 93.3%. The total effective rate of the control group was 70.0%. There was significant difference between the two groups (P <0.05). CONCLUSION: Glycine diazoxide combined with low-dose cisplatin radiosensitization can enhance the radiotherapy effect of advanced esophageal cancer, and is more effective than radiotherapy with glycididazole alone.