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目的探讨西酞普兰与阿米替林治疗脑梗塞后抑郁症的疗效与安全性。方法将48例脑梗塞后抑郁症患者随机分成西酞普兰组与阿米替林组治疗8周,应用汉密尔顿抑郁量表(HAM D)和副反应量表(TESS)评定疗效及安全性。结果西酞普兰与阿米替林疗效相当,但西酞普兰起效快,不良反应轻,而阿米替林副反应大。结论西酞普兰治疗脑梗塞后抑郁症疗效好,起效快,不良反应轻,可作为脑梗塞后抑郁的一线用药。
Objective To investigate the efficacy and safety of citalopram and amitriptyline in the treatment of depression after cerebral infarction. Methods Forty-eight patients with depression after cerebral infarction were randomly divided into citalopram group and amitriptyline group for 8 weeks. HAMD and TESS were used to evaluate the efficacy and safety. Results Citalopram and amitriptyline efficacy, but the rapid onset of citalopram, adverse reactions, and amitriptyline side effects. Conclusion Citalopram treatment of depression after cerebral infarction with good effect, fast onset, adverse reactions, can be used as a first-line depression after cerebral infarction.