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以氢过氧化亚油酸作为脂质过氧化物和亚硒酸钠作为抗氧化剂,作用于培养的人脐静脉内皮细胞,探讨脂质过氧化与抗氧化作用对细胞结构和功能的影响。结果表明,氢过氧化亚油酸能引起内皮细胞收缩、生物膜系统损伤和培养液中6—酮—PGF_(1α)含量减少;加入硒可使细胞脂质过氧化损伤程度减轻。
Hydroperoxide linoleic acid as lipid peroxides and sodium selenite as antioxidants, role in cultured human umbilical vein endothelial cells, to explore lipid peroxidation and antioxidant effects on cell structure and function. The results showed that linoleic acid hydroperoxide induced endothelial cell contraction, biofilm system injury and decreased 6-keto-PGF_ (1α) content in culture medium. Selenium supplementation reduced the lipid peroxidation of cells.