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我们已检测到氯芳类1254处理的大鼠,S9激活的N-亚硝基二甲胺(NDMA)诱发大肠杆菌E.Coli lac I基因N末端DNA的改变,用DNA测序的方法鉴定了125株相互独立的lac I~(-d)突变型。与这种化合物已知的甲基化作用相符,主要的突变类型为G:C→A:T的转换占整个受检突变总数的90％,没有发现检出的非G:C→A:T突变包括2株G:C→
We have detected that chlorinated aromatic 1254-treated rats, S9-activated N-nitrosodimethylamine (NDMA), induced changes in the N-terminal DNA of the E. colioliColi gene and identified 125 Strains independent lac I ~ (-d) mutant. Consistent with the known methylation of this compound, the predominant mutation type was G: C → A: T, which accounted for 90% of the total number of mutations tested, and no detected non-G: C → A: T Mutations include two strains of G: C →