论文部分内容阅读
目的观察米力农治疗肺源性心脏病慢性心功能不全的临床疗效。方法 70例符合纳入标准的肺源性心脏病慢性心功能不全患者,依据就诊先后顺序,用随机数字表法随机分为两组。对照组30例,给予抗炎、纠正水电解质及酸碱平衡紊乱、吸氧、纠正呼吸衰竭、利尿等治疗;治疗组40例,在对照组的基础上加用米力农注射液0.375~0.750μg/(kg.min),持续泵入。2组均以5 d为1个疗程。结果①两组疗效比较:对照组平均秩次为28.95,治疗组平均秩次为40.41。Mann-Whitney U统计量为403.50,Wilcoxon W为868.50,Z检验统计量为Z=-2.517,P=0.012(双侧),两组疗效差异有统计学意义,治疗组优于对照组。②总有效率治疗组为90.00%,对照组为70.00%,两组比较,χ2=4.534,ν=1,P=0.033,差异有统计学意义,治疗组优于对照组。③两组患者均按时完成了治疗,未发现该治疗方法有明显毒副作用。结论米力农治疗肺源性心脏病慢性心功能不全有显著的临床疗效,且毒副作用小,依从性好,是一种安全、有效的强心药物。
Objective To observe the clinical effect of Milrinone on chronic heart failure of pulmonary heart disease. Methods Seventy patients with chronic heart failure of pulmonary heart disease who met the inclusion criteria were randomly divided into two groups according to the order of their visits. Control group of 30 cases, given anti-inflammatory, correct water and electrolyte and acid-base balance disorders, oxygen, respiratory failure correction, diuretic and other treatment; treatment group of 40 patients in the control group based on the use of milrinone injection 0.375 ~ 0.750 μg / (kg.min), continue to pump. 2 groups were 5 d for a course of treatment. Results ① The two groups were compared: the average rank of the control group was 28.95, the average rank of the treatment group was 40.41. Mann-Whitney U statistic was 403.50, Wilcoxon W was 868.50 and Z test statistic was Z = -2.517, P = 0.012 (both sides). There was significant difference between two groups in curative effect, and the treatment group was superior to the control group. ② The total effective rate was 90.00% in the treatment group and 70.00% in the control group. Χ2 = 4.534, ν = 1, P = 0.033, the difference was statistically significant. The treatment group was superior to the control group. The two groups of patients completed the treatment on time, did not find the treatment has obvious side effects. Conclusion Milrinone is a safe and effective drug for the treatment of chronic heart failure of pulmonary heart disease with obvious clinical curative effect, small toxic and side effects and good compliance.