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目的观察他汀类药物阿托伐他汀(立普妥)短期应用对慢性心力衰竭患者心功能、细胞因子(肿瘤坏死因子-α、白细胞介素-6)水平的作用。方法98例慢性心力衰竭患者(NYHA分级Ⅱ~Ⅲ级)随机分成两组,治疗组(48例)和对照组(50例)。对照组给予强心、利尿、扩血管治疗,治疗组在此基础上加用立普妥10mg/d,共12周。治疗前后检查心脏超声,评估心功能,测定肿瘤坏死因子-α、白细胞介素-6和血脂水平。结果12周后治疗组低密度脂蛋白水平明显降低(P<0.05)。心功能按NYHA分级治疗组与对照组相比有明显改善(P<0.01),左室射血分数有明显提高(P<0.05),治疗组治疗后肿瘤坏死因子-α、白细胞介素6水平明显降低(P<0.05),而对照组前后比较无改变。结论阿托伐他汀能降低血浆细胞因子(肿瘤坏死因子-α、白细胞介素-6)水平,改善心脏功能,有益于慢性心力衰竭的治疗。
Objective To observe the effect of short-term statin use of atorvastatin (Lipitor) on the cardiac function, cytokines (tumor necrosis factor-α, interleukin-6) in patients with chronic heart failure. Methods A total of 98 patients with chronic heart failure (NYHA class Ⅱ ~ Ⅲ) were randomly divided into two groups: treatment group (48 cases) and control group (50 cases). Control group was given cardiac, diuretic and vasodilator therapy. On the basis of this, the treatment group received Lipitor 10 mg / d for 12 weeks. Cardiac echocardiography was performed before and after treatment, cardiac function was assessed, and tumor necrosis factor-alpha, interleukin-6, and lipid levels were measured. Results After 12 weeks, the level of LDL in treatment group was significantly lower (P <0.05). Compared with the control group, cardiac function was significantly improved in the NYHA class (P <0.01) and left ventricular ejection fraction (P <0.05). The levels of tumor necrosis factor-α, interleukin 6 (P <0.05), but no change in the control group before and after. Conclusions Atorvastatin can reduce the levels of plasma cytokines (tumor necrosis factor-α and interleukin-6), improve cardiac function and benefit the treatment of chronic heart failure.