Objective: To optimize the ionic liquid based microwave-assisted extraction(IL-MAE)of polyphenolic content from Peperomia pellucida(L) Kunth.Methods: The IL-MAE factors as experimental design parameters, including microwave power, extraction time, ionic liquid concentration, and liquid–solid ratio had been involved. Response surface methodology and Box–Behnken design were used to obtain predictive model(multivariate quadratic regression equation) and optimization of the extraction process. The response surface was analyzed by using the yields of total polyphenolic content as response value.Results: Based on the obtained results the optimum extraction condition, including microwave power of 30% Watts, extraction time of 18.5 min, the ionic liquid concentration of 0.79 mol/L, and the liquid–solid ratio of 10.72 mL/g 1-Buthyl-3-methylimidazolium tetrafluoroborate([bmim]BF_4) as a solvent was selected. The regression model was obtained to predicts the yields from Peperomia pellucida:Y = 30.250 – 1.356X_1+ 2.655X_2+ 2.252X_3– 0.565X_4+ 0.990 X_1X_3– 8.172X_1X_4– 3.439 X_3X_4– 4.178 X_1~2– 3.210 X_3~2– 6.786 X_4~2– 7.290 X_1~2X_3+ 5.575X1_X_3~2– 4.843 X_3~2X_4 with R~2= 0.82519. Scale-up confirmation test was obtained the maximum yields of total polyphenolics content with the amount of 31.172 5 mg GAE/g.Conclusions: The IL-MAE method produced a higher extraction polyphenolic and performed rapidly, easily and efficiently. Objective: To optimize the ionic liquid based microwave-assisted extraction (IL-MAE) of polyphenolic content from Peperomia pellucida (L) Kunth. Methods: The IL-MAE factors as experimental design parameters, including microwave power, extraction time, ionic liquid concentration , and liquid-solid ratio had been involved. Response surface methodology and Box-Behnken design were used to obtain predictive model (multivariate quadratic regression equation) and optimization of the extraction process. The response surface was analyzed by using the yield of total polyphenolic content as response value. Results: Based on the obtained results of the optimum extraction condition, including microwave power of 30% Watts, extraction time of 18.5 min, the ionic liquid concentration of 0.79 mol / L, and the liquid-solid ratio of 10.72 mL / g 1-Buthyl-3-methylimidazolium tetrafluoroborate ([bmim] BF_4) as a solvent was selected. The regression model was obtained to predicts the yield from Peperomia pellucida: Y = 30.250 - 1.356X_1 + 2.655X_2 + 2.252X_3 - 0.565X_4 + 0.990 X_1X_3 - 8.172X_1X_4 - 3.439 X_3X_4 - 4.178 X_1 - 2- 3.210 X_3 - 2- 6.786 X_4 - 2- 7.290 X_1 - 2X_3 + 5.575X1_X_3 - 2 - 4.843 X_3 - 2X_4 with R ~ 2 = 0.82519. Scale-up confirmation test was obtained the maximum yield of total polyphenolics content with the amount of 31.172 5 mg GAE / g.Conclusions: The IL-MAE method produced a higher extraction polyphenolic and performed rapidly, easily and efficiently