We have analyzed the D0 →π+π- decay with αs corrections in quantum chromodynamic (QCD) factorization and with the soft-gluon corrections in the light cone QCD sum rules. The soft-gluon effects are firstly calculated in the decay channel. The results show that once the factorization contributions, the αs corrections, and the soft-gluon effects are all considered, we can satisfactorily explain the experimental data in the decay channel.