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目的探讨小剂量环磷酰胺(CTX)与血浆置换(PE)治疗重症系统性红斑狼疮(SLE)的临床疗效。方法对我院收治的20例重症SLE患者进行小剂量环磷酰胺与血浆置换治疗,观察治疗后临床症状(面部红斑、关节疼痛、发热)缓解情况和活动性指标(抗ds-DNA抗体、抗SM抗体、Scr、24小时尿蛋白、血沉、补体C3)等变化。结果20例重症SLE患者临床症状完全缓解且快,活动性指标有显著变化(P<0.05)。结论血浆置换可较快地控制重症SLE活动,联合应用小剂量环磷酰胺,提高近期及远期临床疗效。
Objective To investigate the clinical efficacy of low dose cyclophosphamide (CTX) and plasma exchange (PE) in the treatment of severe systemic lupus erythematosus (SLE). Methods Twenty patients with severe SLE admitted to our hospital were treated with low dose cyclophosphamide and plasma exchange. The clinical symptoms (facial erythema, joint pain and fever) and the activity index (anti-dsDNA antibody, anti- SM antibody, Scr, 24-hour urinary protein, ESR, complement C3) and other changes. Results The clinical symptoms of 20 patients with severe SLE were completely relieved and had fast and active indexes changed significantly (P <0.05). Conclusion Plasma exchange can control severe SLE quickly, and the combination of low dose cyclophosphamide can improve the clinical efficacy in the short and long term.