【摘 要】
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Poly (γ-glutamic acid) (γ-PGA) has been found widespread applications in biomedical field because of its excellent water solubility,biocompatibility,and bioac
【机 构】
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State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chine
论文部分内容阅读
Poly (γ-glutamic acid) (γ-PGA) has been found widespread applications in biomedical field because of its excellent water solubility,biocompatibility,and bioactivity.Herein,a water-insoluble γ-PGA antibac-terial compound is facilely fabricated via one-pot electrostatic assembly of γ-PGA with cationic ethyl lauroyl arginate (ELA).The functionalized γ-PGA compound (γ-PGA-ELA) ethanol solution can facilely produce colorless and transparent coatings on various inorganic,metal,and polymeric substrates,espe-cially for the lumen of slender catheters (length up to 2 m,and inner diameter down to 1 mm).The functionalized γ-PGA coating presents remarkable antibacterial efficacy in vitro and in vivo.In addition,the y-PGA compound is used as antibacterial additives of polyolefin via melting extrusion,and the as-prepared antibacterial polyolefin demonstrates advantageous antibacterial efficacy.More importantly,the functionalized γ-PGA coating exhibit good hemocompatibility,low cytotoxicity,and satisfactory histocompatibility.The as-proposed γ-PGA compound has a great potential to serve as a safe and multi-functional antibacterial candidate to combat biomedical devices-related infections.
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