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在微波辐射条件下,通过巯基唑类化合物与芳基碘化物的反应,得到了系列芳基硫醚化合物.当微波输出功率为30 W、溶剂为N,N-二甲基甲酰胺(DMF)、反应时间为15 min时产率可达88%.同时,通过高效液相色谱分析法分别对微波辐射和传统油浴加热条件下的反应结果进行了讨论,结果表明:微波辐射条件下,反应选择性高、时间短、副产物少.此方法有望成为一种高效、温和、对环境友好的合成芳基硫醚的方法.
Under the condition of microwave irradiation, a series of arylsulfide compounds were obtained by the reaction of thiolazoles with aryl iodides. When the microwave output power was 30 W and the solvent was N, N-dimethylformamide (DMF) , The reaction time is 15 min, the yield can reach 88% .At the same time, the reaction results of microwave irradiation and traditional oil bath heating conditions are discussed by HPLC, respectively. The results show that under the conditions of microwave irradiation, High selectivity, short time, and few by-products.This method is expected to be an efficient, mild and environmentally friendly synthetic aryl sulfide.