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目的探讨甲状腺透明变梁状肿瘤的病理特征。方法对1例甲状腺肿瘤的临床病理资料进行光镜、电镜和免疫组化标记检查,选用的抗体TTF1、Ki-67、Ki-67(MIB-1)、E-cadherin、calcitonin、CgA、TFE3、Syn、AFP、EMA、CKpan和p53,并复习文献。结果患者为青年男性,肿瘤位于甲状腺左叶。大体呈灰白色球形实性肿块;组织学见肿瘤细胞呈梁状、腺泡样排列,细胞呈多角形或梭形;核仁周围有空晕,易见核内包涵体,小梁内见透明变物质并与瘤细胞融合。免疫组化显示肿瘤细胞细胞膜MIB-1强(+)。电镜可见细胞质富含中间丝。结论甲状腺透明变梁状肿瘤中呈梁状结构的肿瘤细胞细胞膜具有特征性的MIB-1(+),该肿瘤形态易与甲状腺乳头状癌实体亚型和甲状腺髓样癌相混淆。现在认为,该肿瘤是一种低度恶性潜能的肿瘤。
Objective To investigate the pathological features of thyroid transparent metastatic tumors. Methods The clinical and pathological data of one case of thyroid tumor were examined by light microscopy, electron microscopy and immunohistochemistry. The antibody levels of TTF1, Ki-67, MIB-1, E-cadherin, calcitonin, CgA, TFE3, Syn, AFP, EMA, CKpan and p53, and reviewed the literature. Results The patients were young men and the tumor was located in the left lobe of thyroid. Generally gray-white spherical solid mass; Histology see tumor cells were beam-like, acinar-like arrangement, the cells were polygonal or fusiform; halo halo around the nucleolus, easy to see inclusions in the nucleus, trabecular see transparent Material and fusion with tumor cells. Immunohistochemistry showed strong MIB-1 (+) in the tumor cell membrane. Electron microscopy shows that the cytoplasm is rich in intermediate filaments. CONCLUSION: MIB-1 (+), a characteristic cell membrane of tumor cells with a beam-like structure in the thyroid translucent beryllium tumor, is easily confused with thyroid papillary carcinoma subtype and medullary thyroid carcinoma. Now that the tumor is a low-potential malignancy of the tumor.