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目的探讨血管内皮生长因子-C(VEGF-C)在胃癌中的表达及临床意义。方法收集潍坊市妇幼保健院、潍坊市人民医院2008年1月—2011年1月手术切除的80例胃癌原发病灶,均有完整的临床资料,术前都未经放疗、化疗。正常胃部组织26例。采用免疫组化PV-6000法检测VEGF-C在80例胃癌术后病理标本和26例正常组织中的表达。结果 VEGF-C的阳性表达主要为胞浆着色。VEGF-C在胃癌中的表达高于在正常胃部组织中的表达,差异有显著性(P<0.05),VEGF-C的阳性表达与胃癌患者的性别、年龄、肿瘤的大小、分化无明显相关性(P﹥0.05),VEGF-C的阳性表达随肿瘤浸润深度的增加而增加(P<0.05),随淋巴结的转移而增加(P<0.05),临床分化较晚,阳性率较高(P<0.05)。结论 VEGF-C和胃癌的浸润和转移密切相关。
Objective To investigate the expression and clinical significance of vascular endothelial growth factor-C (VEGF-C) in gastric cancer. Methods Weifang City Maternal and Child Health Hospital, Weifang People’s Hospital January 2008 -2011 January surgical resection of 80 cases of primary gastric cancer, have complete clinical data, without preoperative radiotherapy and chemotherapy. Normal gastric tissue in 26 cases. Immunohistochemistry PV-6000 method was used to detect the expression of VEGF-C in 80 cases of gastric cancer and 26 cases of normal tissue. Results The positive expression of VEGF-C was mainly cytoplasm staining. The expression of VEGF-C in gastric cancer was higher than that in normal gastric tissue, the difference was significant (P <0.05). The positive expression of VEGF-C was not related to the gender, age, tumor size and differentiation The positive expression of VEGF-C increased with the depth of tumor invasion (P <0.05), increased with lymph node metastasis (P <0.05), the clinical differentiation was late, and the positive rate was higher P <0.05). Conclusion The infiltration and metastasis of VEGF-C and gastric cancer are closely related.