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目的:比较不同剂量泮托拉唑联合醋酸奥曲肽治疗对上消化道出血患者生活质量的影响。方法:将120例上消化道出血患者随机分为对照组60例,采用泮托拉唑注射液40mg联合醋酸奥曲肽注射液0.1mg加入5%葡萄糖2注射液50ml中静脉滴注,2次/d,30~60min内滴完;观察组60例,采用泮托拉唑注射液80mg联合醋酸奥曲肽注射液0.2mg加入5%葡萄糖注射液250ml中静脉滴注,1次/d,30~60min内滴完。两组疗程均为6d。观察两组治疗前后生活质量改善情况。结果:两组治疗前BREF中各项评分比较,差异无统计学意义(P>0.05);出院时、治疗后第3个月和6个月,两组BREF中各项评分与治疗前比较,差异有统计学意义(P<0.05);观察组出院时BREF中各项评分优于对照组(P<0.05)。但治疗后第3个月和6个月,观察组BREF中各项指标评分与对照组比较,差异均无统计学意义(P>0.05)。观察组治疗后第3、6个月再出血发生率低于对照组,但差异无统计学意义(P>0.05)。结论:两种不同剂量治疗方法均可改善上消化道出血患者的生活质量。
Objective: To compare the effects of different doses of pantoprazole and octreotide acetate on the quality of life of patients with upper gastrointestinal bleeding. Methods: 120 cases of upper gastrointestinal bleeding were randomly divided into control group of 60 cases, the use of pantoprazole injection 40mg combined with octreotide acetate 0.1mg injection of 5% glucose 2 injection 50ml intravenous infusion, 2 times / d , 30 ~ 60min drip finished; observation group 60 cases, the use of pantoprazole injection 80mg combined with octreotide acetate injection 0.2mg 5% glucose injection 250ml intravenous infusion, 1 / d, 30 ~ 60min within the drop Finish. Two groups of treatment are 6d. The quality of life before and after treatment was observed in both groups. Results: There was no significant difference between the two groups in BREF score before treatment (P> 0.05). At discharge, at 3 months and 6 months after treatment, the scores of BREF in both groups were significantly lower than those before treatment The difference was statistically significant (P <0.05). The scores of BREF in the observation group were better than those in the control group at discharge (P <0.05). However, in the third month and the sixth month after treatment, the score of BREF in the observation group was not significantly different from the control group (P> 0.05). The incidence of rebleeding in the observation group at 3 and 6 months after treatment was lower than that in the control group, but the difference was not statistically significant (P> 0.05). Conclusion: Two different doses of treatment can improve the quality of life of patients with upper gastrointestinal bleeding.