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P21活化的蛋白激酶(p21-activated kinases,PAKs)是Rho家族中GTP酶重要效应物,已证实对细胞繁殖和生存有重要意义。研究发现PAKs与神经元树突发育、细胞骨架的形成以及在细胞信号转导等方面起重要作用。本研究对Ⅰ类PAKs在神经退行性疾病中作用研究进展作一综述。
P21-activated kinases (PAIs) are important GTPases in the Rho family and have been shown to be important for cell proliferation and survival. It is found that PAKs plays an important role in the dendritic development of neurons, the formation of cytoskeleton and cell signal transduction. This review summarizes the research progress on the role of class I PAKs in neurodegenerative diseases.