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目的 :对比研究长期应用培哚普利和氨氯地平逆转原发性高血压 (EH)伴左心室肥厚 (L VH)的作用。 方法 :将 114例 EH伴 L VH的患者分为培哚普利组 (n=5 8)和氨氯地平组 (n=5 6 ) ,于服药前及服药后 6、12、36个月分别测定左心室舒张末内径、舒张期室间隔厚度、左心室后壁厚度、左心室射血分数、心排血量、A/ E峰值。 结果 :两组治疗前后比较左心室射血分数、心排血量均无变化 ,而 A/ E峰值则明显降低 ;左心室重量指数、左心室舒张末内径、舒张期室间隔厚度、左心室后壁厚度在培哚普利组明显下降 ,而在氨氯地平组则无变化。 结论 :培哚普利和氨氯地平均能明显改善左心室舒张功能 ,但仅培哚普利能明显减轻左心室肥厚。
OBJECTIVE: To compare the long-term use of perindopril and amlodipine to reverse the effects of essential hypertension (EH) with left ventricular hypertrophy (L VH). Methods: A total of 114 patients with EH with L VH were divided into perindopril group (n = 5 8) and amlodipine group (n = 5 6), before treatment and 6,12,36 months Left ventricular end diastolic diameter, diastolic interventricular septum thickness, left ventricular posterior wall thickness, left ventricular ejection fraction, cardiac output and A / E peak were measured. Results: Left ventricular ejection fraction and left ventricular ejection fraction did not change before and after treatment, but A / E peak decreased significantly. Left ventricular mass index, left ventricular end-diastolic diameter, diastolic ventricular septum thickness, Wall thickness decreased significantly in the perindopril group and no change in the amlodipine group. CONCLUSION: Perindopril and amlodipine significantly improve left ventricular diastolic function, but only perindopril can significantly reduce left ventricular hypertrophy.