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目的:观察三羊益心康胶囊对麻醉犬血流动力学和心肌耗氧量的影响。方法:采用麻醉犬在体心脏实验法,经十二指肠给予三羊益心康胶囊,于给药后不同时间点测定血流动力学和心肌耗氧量各项参数。结果:三羊益心康胶囊能明显增加麻醉犬冠脉血流量、心输出量、心搏出量、心脏指数、心搏指数,降低总外周阻力和冠状动脉阻力,减少心肌耗氧量、心肌耗氧指数及心肌氧摄取率。结论:三羊益心康胶囊能明显改善麻醉犬血流动力学,降低心肌耗氧量。
Objective: To observe the effects of Sanyang Yixinkang Capsule on hemodynamics and myocardial oxygen consumption of anesthetized dogs. METHODS: Anesthetized dogs were tested in vivo by heart method and were given Sanyang Yixinkang Capsules by duodenum. The parameters of hemodynamics and myocardial oxygen consumption were measured at different time points after administration. Results: Sanyang Yixinkang Capsule can significantly increase coronary blood flow, cardiac output, cardiac output, heart index and heart rate index of anesthetized dogs, reduce total peripheral resistance and coronary resistance, and reduce myocardial oxygen consumption and myocardial Oxygen consumption index and myocardial oxygen uptake rate. Conclusion: Sanyang Yixinkang Capsule can significantly improve the hemodynamics of anesthetized dogs and reduce the oxygen consumption of the myocardium.