喉癌好发于男性,男女比例约为20:1,男性好发喉癌的原因至今尚无满意解释。由于喉头是显示第二性徵的器官,易受雄激素刺激而发生变化。Kambic及Lenart给雌狗注射睾丸酮后发生急性喉炎,并伴有声带上皮过度角化及有丝分裂增加。氏等还报告妇女接受高剂量睾丸酮注射6—8周后发生声嘶,声带发红,上皮有增殖性变化。 Laryngeal cancer occurs in men, the ratio of men to women is about 20: 1, the reason men have good laryngeal cancer so far no satisfactory explanation. Because the throat is an organ exhibiting secondary sexual characteristics, it is susceptible to androgen changes. Acute laryngitis occurs following Kambic and Lenart injection of testosterone in females, accompanied by hyperkeratosis of the vocal cord epithelium and increased mitosis. Et al. Also reported that women developed hoarseness 6-8 weeks after high-dose testosterone injections, red vocal folds, and proliferative changes in the epithelium.