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本文综述与人体有关的三种重要的微量元素锌、锰和铜研究的进展,特别着重体内代谢及失调方面的生理、生化和病理变化。一、锌1.吸收:一个70公斤的人体含1.4～2.3克锌。成人大约每天摄入10～15毫克锌,由小肠吸收5毫克左右。锌在小肠的吸收不是简单的扩散,而是受某种机理调节的。胃肠外给小鼠过量的~(65)Zn,可使大便中~(65)Zn排泄加速,而口服不行。在身体锌负荷增加时~(65)Zn的吸收减少。Evans等指出,锌吸收的变化与肠粘膜锌含量有关,后者又受血浆锌含量的调节。
This review summarizes the progress made in the study of three important trace metals, zinc, manganese and copper, with particular emphasis on the physiological, biochemical and pathological changes in metabolism and disorders. First, zinc 1. Absorption: A 70 kg body contains 1.4 ~ 2.3 grams of zinc. Adults intake of about 10 ~ 15 mg of zinc a day, about 5 mg absorbed by the small intestine. Zinc absorption in the small intestine is not a simple diffusion, but by some mechanism of regulation. Excessive administration of ~ (65) Zn to mice by parenteral administration can exacerbate ~ (65) Zn excretion in the stool without oral administration. In the body increased zinc load ~ (65) Zn absorption decreased. Evans pointed out that changes in zinc absorption and intestinal mucosal zinc content, the latter by the regulation of plasma zinc content.