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细胞融合,是生物体在发展和达到动态平衡过程中产生的。而肿瘤的发展是一个多步骤的复杂过程,从肿瘤的发生及生长,到肿瘤发生转移,这些过程都与细胞融合关系密切。目前对细胞融合与肿瘤之间关系的研究较多,主要集中于几个方面:细胞融合研究机制;不同细胞之间的融合;细胞融合与其它学说如上皮-间质转化(EMT)、染色体非整倍性、肿瘤异质性等之间的关系;细胞融合与血管生成和肿瘤转移的研究等等。本文主要从以上几个方面入手,初步探究细胞融合与肿瘤之间的关系,从而为肿瘤治疗提供新的目标和方向。
Cell fusion is the process by which organisms develop and reach homeostasis. The development of tumors is a multi-step complex process, from the occurrence and growth of tumors to tumor metastasis, these processes are closely related to cell fusion. At present, there are many researches on the relationship between cell fusion and tumor, which mainly focus on several aspects: cell fusion research mechanism; fusion between different cells; cell fusion and other theories such as epithelial-mesenchymal transition (EMT) Euploidy, tumor heterogeneity, etc. The relationship between cell fusion and angiogenesis and tumor metastasis and so on. This article mainly from the above aspects to initially explore the relationship between cell fusion and cancer, so as to provide new goals and directions for cancer treatment.