目的观察埃索美拉唑、左氧氟沙星、阿莫西林1周疗法根除幽门螺杆菌(Hp)的疗效。方法选择90例Hp阳性消化性溃疡患者,随机分为治疗组与对照组各45例。治疗组采用埃索美拉唑加左氧氟沙星加阿莫西林,治疗7 d后继续用埃索美拉唑20 mg,1次/d,疗程为3周。对照组采用埃索美拉唑加克拉霉素,加阿莫西林,治疗7 d后继续用埃索美拉唑20 mg,1次/d,疗程为3周。疗程结束4周后复查胃镜和Hp检查,观察Hp根除率,症状缓解率、溃疡愈合率和不良反应。结果治疗组和对照组的症状缓解率分别为95.55%和91.11%,溃疡愈合率分别为93.33%和91.11%,两组比较差异无统计学意义(P>0.05),治疗组和对照组的Hp根除率分别为93.33%和75.55%,差异有统计学意义(P<0.05)。结论治疗组Hp根除率优于对照组,能有效控制消化性溃疡、促进其愈合、缓解其临床症状,安全且耐受性好,是一种较为理想的治疗方案。 Objective To observe the efficacy of esomeprazole, levofloxacin and amoxicillin in the treatment of Helicobacter pylori (HP) for one week. Methods Ninety patients with Hp-positive peptic ulcer were randomly divided into treatment group (n = 45) and control group (n = 45). Treatment group with esomeprazole plus levofloxacin plus amoxicillin, 7 days after treatment with esomeprazole 20 mg, 1 / d, course of treatment for 3 weeks. The control group was treated with esomeprazole plus clarithromycin plus amoxicillin. After 7 days of treatment, esomeprazole 20 mg once daily was given for 3 weeks. Four weeks after the end of treatment, gastroscopy and Hp examination were performed. Hp eradication rate, symptom relief rate, ulcer healing rate and adverse reactions were observed. Results The remission rates of the treatment group and the control group were 95.55% and 91.11%, respectively, and the healing rates of ulcer were 93.33% and 91.11% respectively. There was no significant difference between the two groups (P> 0.05) The eradication rates were 93.33% and 75.55%, respectively, with significant difference (P <0.05). Conclusions The Hp eradication rate in the treatment group is better than that in the control group, which can effectively control the peptic ulcer, promote its healing, relieve the clinical symptoms, be safe and well tolerated, and it is an ideal treatment plan.