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目的了解国产b型流感嗜血杆菌结合疫苗(Hib结合疫苗)和进口Hib结合疫苗的接种副反应发生率,探讨推广国产Hib结合疫苗的价值。方法随机抽取2012年我辖区接种国产和进口Hib结合疫苗的5岁以内儿童586例为观察对象,观察组306名儿童接种国产Hib结合疫苗,对照组280名儿童接种进口葛兰素史克Hib结合疫苗,对接种后副反应进行观察。结果观察组与对照组副反应发生率比较差异无统计学意义(P>0.05)。结论国产与进口Hib结合疫苗的接种后副反应发生率较低,基本相同,都具有较高安全性,而国产Hib结合疫苗价格便宜,更值得广泛推广使用。
Objective To understand the incidence of domestic immunization with Hib conjugate vaccine (Hib conjugate vaccine) and imported Hib conjugate vaccine and to explore the value of promoting domestic Hib conjugate vaccine. Methods A total of 586 children aged under 5 years who were vaccinated domestic and imported Hib conjugate vaccine in our area were randomly selected for observation in 2012. 306 children in the observation group were vaccinated with domestic Hib conjugate vaccine and 280 children in control group were vaccinated with imported GSK Hib conjugate vaccine , After inoculation side effects were observed. Results There was no significant difference in the incidence of side effects between observation group and control group (P> 0.05). Conclusions Domestic and imported Hib conjugate vaccines have a lower incidence of side effects after inoculation, are basically the same, and have high safety. However, the domestic Hib conjugate vaccine is cheaper and more widely used.